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Cheap Flights from Des Moines (DSM) to Charleston (CHS)

Compare Des Moines to Charleston flight deals

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Flight deals from Des Moines to Charleston

Looking for a cheap last-minute deal or the best return flight from Des Moines to Charleston? Find the lowest prices on one-way and return tickets right here.
Charleston.£204 per passenger.Departing Sun, 1 Feb, returning Sun, 15 Feb.Return flight with Allegiant Air and Breeze Airways.Outbound indirect flight with Allegiant Air, departs from Des Moines on Sun, 1 Feb, arriving in Charleston.Inbound indirect flight with Breeze Airways, departs from Charleston on Sun, 15 Feb, arriving in Des Moines.Price includes taxes and charges.From £204, select.
Charleston.£232 per passenger.Departing Sun, 1 Mar, returning Wed, 4 Mar.Return flight with Frontier Airlines and Spirit Airlines.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Sun, 1 Mar, arriving in Charleston.Inbound indirect flight with Spirit Airlines, departs from Charleston on Wed, 4 Mar, arriving in Des Moines.Price includes taxes and charges.From £232, select.
Charleston.£235 per passenger.Departing Tue, 24 Feb, returning Tue, 3 Mar.Return flight with American Airlines.Outbound indirect flight with American Airlines, departs from Des Moines on Tue, 24 Feb, arriving in Charleston.Inbound indirect flight with American Airlines, departs from Charleston on Tue, 3 Mar, arriving in Des Moines.Price includes taxes and charges.From £235, select.
Charleston.£269 per passenger.Departing Wed, 6 May, returning Sun, 10 May.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Des Moines on Wed, 6 May, arriving in Charleston.Inbound indirect flight with Southwest Airlines, departs from Charleston on Sun, 10 May, arriving in Des Moines.Price includes taxes and charges.From £269, select.
Charleston.£276 per passenger.Departing Mon, 26 Jan, returning Sat, 7 Feb.Return flight with Allegiant Air and Spirit Airlines.Outbound indirect flight with Allegiant Air, departs from Des Moines on Mon, 26 Jan, arriving in Charleston.Inbound indirect flight with Spirit Airlines, departs from Charleston on Sat, 7 Feb, arriving in Des Moines.Price includes taxes and charges.From £276, select.
Charleston.£283 per passenger.Departing Sun, 25 Jan, returning Wed, 28 Jan.Return flight with Allegiant Air and Breeze Airways.Outbound indirect flight with Allegiant Air, departs from Des Moines on Sun, 25 Jan, arriving in Charleston.Inbound indirect flight with Breeze Airways, departs from Charleston on Wed, 28 Jan, arriving in Des Moines.Price includes taxes and charges.From £283, select.
Charleston.£288 per passenger.Departing Mon, 1 Jun, returning Fri, 5 Jun.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Mon, 1 Jun, arriving in Charleston.Inbound indirect flight with United, departs from Charleston on Fri, 5 Jun, arriving in Des Moines.Price includes taxes and charges.From £288, select.
Charleston.£306 per passenger.Departing Fri, 17 Apr, returning Mon, 20 Apr.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Des Moines on Fri, 17 Apr, arriving in Charleston.Inbound indirect flight with Southwest Airlines, departs from Charleston on Mon, 20 Apr, arriving in Des Moines.Price includes taxes and charges.From £306, select.

Find the cheapest month to fly from Des Moines to Charleston

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Charleston flights are currently cheapest in February.
Jan
from £283
Feb
from £204
Mar
from £232
Apr
from £306
May
from £269
Jun
from £288
Jul
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Aug
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Sep
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Oct
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Nov
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Dec
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Des Moines to Charleston: Alternative routes

Compare routes from Des Moines to Charleston below. You may find an airport to fly into that's cheaper, faster, or easier than Charleston.

Des Moines to Charleston: Flight information

The things to know before you go.
Cheapest flight found£204
Cheapest month to flyFebruary

Finding cheap flights from Des Moines to Charleston: Frequently asked questions

The best price we found for a return flight from Des Moines to Charleston is £204. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to Charleston. But we found flights with one or more stops from £204.
As of January 2026, there are no flights flying from Des Moines to Charleston.
The cheapest month to fly from Des Moines to Charleston is usually February.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Charleston Airport on Sunday, 1 February 2026.
No airlines currently offer direct flights between Des Moines Airport and Charleston Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Charleston but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Charleston is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Allegiant Air offers the cheapest flight tickets to Charleston.

Travelling from Des Moines International Airport (DSM) to Charleston International Airport (CHS): what you need to know

  • The timezone in Charleston is UTC-4, which is one hour ahead of Des Moines.

  • Arriving two hours before an international flight and one hour ahead of a domestic departure are travel rules to live by. Be at the airport on time to board your DSM to CHS flight.

  • Travelling during a peak time like July? Major public holidays and other popular periods can mean longer queues at check-in and security. Play things extra safe and get there up to four hours ahead of an international flight and two hours before a domestic departure.

  • If you want to break up your flight, simply deselect 'Direct flights only' when searching for your ticket from Des Moines International Airport to Charleston International Airport. These are the top stopovers between DSM and CHS:

    • Hartsfield-Jackson Atlanta International Airport

    • O'Hare International Airport

    • Charlotte Douglas International Airport

How to find the cheapest flights from Des Moines International Airport (DSM) to Charleston International Airport (CHS)

  • Currently, £118 is the cheapest price we've found for a one-way Des Moines International Airport to Charleston International Airport flight. The best price for a return ticket is £204. Keep in mind that fares could change due to demand at the time of booking.

  • It's often best to book early if you want to find cheap tickets from DSM to CHS. That's because flight prices are based on demand, which tends to rise closer to departure.

  • If you're willing to be flexible with your travel plans, use the 'Whole month' tool. It'll find the cheapest price in each month when searching for a flight from Des Moines International Airport to Charleston International Airport.

  • Cut down on the time spent looking for cheap flights from DSM to CHS by creating a Price Alert. You'll receive an email or push notification on the app when a new low fare is offered.

  • Tailor your trip using filters. Pick your ideal arrival and departure times, total journey duration and airlines. You can also sort the results by 'Fastest,' 'Best' or 'Cheapest' flights from Des Moines International Airport to Charleston International Airport.

Handy information about Des Moines International Airport (DSM)

  • DSM's address is 5800 Fleur Drive, Suite 201.

  • Des Moines International Airport gets top marks for its on-time performance. 80.45% of flights that take off from DSM arrive at their destination without delay.

  • To get to Des Moines International Airport from central Des Moines, it'll take around 15 minutes if you're going by car. Of course, this depends on traffic. It's approximately 6 miles from the airport to the city centre.

  • Expect a trip time of around 45 minutes when using public transport.

  • Get your travels off to a hassle-free start by staying near DSM. Whether you have an early flight from Des Moines International Airport to Charleston International Airport or just don't like being rushed, these hotels are perfect:

Arriving at Charleston International Airport (CHS)

Getting from Charleston International Airport (CHS) to central Charleston

  • Charleston International Airport to central Charleston has a drive time of around 30 minutes. It's approximately 13 miles away.

  • When travelling by public transport, expect a journey of around 3 hours 35 minutes.

When to fly to Charleston International Airport (CHS)

  • The quietest month for a flight from Des Moines International Airport to Charleston International Airport is April, while July is the busiest. Pick the best time to go to Charleston based on whether you prefer a more relaxed vibe or a faster pace.

  • When booking your flight from Des Moines International Airport to Charleston International Airport, consider the type of weather you like. July is the warmest month in Charleston, with the temperature ranging from 24ºC (75ºF) to 32ºC (90ºF).

  • If you like travelling in cooler conditions, look for a cheap ticket from DSM to CHS in January. Temperatures average between 4ºC (39ºF) and 17ºC (63ºF) then.

Explore more of United States

  • Jacksonville is just one of the many places in United States waiting to be discovered once you've taken in the sights of Charleston. Around 200 miles away to the south-west, popular attractions include Jacksonville Zoo and Gardens, The Cummer Museum of Art & Gardens and Friendship Fountain.

  • Around 180 miles north of Charleston, Charlotte is another essential stop in United States. Experience this destination's highlights firsthand at NASCAR Hall of Fame, Freedom Park and Carolinas Aviation Museum.

Plan the rest of your trip from Des Moines to Charleston

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.