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Cheap Flights from Buffalo Niagara (BUF) to Knoxville (TYS)

Compare Buffalo Niagara to Knoxville flight deals

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Flight deals from Buffalo Niagara to Knoxville

Looking for a cheap last-minute deal or the best return flight from Buffalo Niagara to Knoxville? Find the lowest prices on one-way and return tickets right here.
Knoxville.£195 per passenger.Departing Sat, 2 May, returning Thu, 7 May.Return flight with Frontier Airlines and Allegiant Air.Outbound indirect flight with Frontier Airlines, departs from Buffalo Niagara on Sat, 2 May, arriving in Knoxville.Inbound indirect flight with Allegiant Air, departs from Knoxville on Thu, 7 May, arriving in Buffalo Niagara.Price includes taxes and charges.From £195, select.
Knoxville.£235 per passenger.Departing Wed, 22 Apr, returning Sun, 26 Apr.Return flight with Frontier Airlines and Allegiant Air.Outbound indirect flight with Frontier Airlines, departs from Buffalo Niagara on Wed, 22 Apr, arriving in Knoxville.Inbound indirect flight with Allegiant Air, departs from Knoxville on Sun, 26 Apr, arriving in Buffalo Niagara.Price includes taxes and charges.From £235, select.
Knoxville.£243 per passenger.Departing Wed, 25 Mar, returning Fri, 27 Mar.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Buffalo Niagara on Wed, 25 Mar, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Fri, 27 Mar, arriving in Buffalo Niagara.Price includes taxes and charges.From £243, select.
Knoxville.£250 per passenger.Departing Fri, 19 Jun, returning Tue, 23 Jun.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Buffalo Niagara on Fri, 19 Jun, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Tue, 23 Jun, arriving in Buffalo Niagara.Price includes taxes and charges.From £250, select.
Knoxville.£291 per passenger.Departing Fri, 23 Oct, returning Sun, 25 Oct.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Buffalo Niagara on Fri, 23 Oct, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Sun, 25 Oct, arriving in Buffalo Niagara.Price includes taxes and charges.From £291, select.
Knoxville.£332 per passenger.Departing Thu, 16 Jul, returning Wed, 22 Jul.Return flight with United.Outbound indirect flight with United, departs from Buffalo Niagara on Thu, 16 Jul, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Wed, 22 Jul, arriving in Buffalo Niagara.Price includes taxes and charges.From £332, select.
Knoxville.£482 per passenger.Departing Fri, 27 Feb, returning Sun, 1 Mar.Return flight with Delta.Outbound indirect flight with Delta, departs from Buffalo Niagara on Fri, 27 Feb, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Sun, 1 Mar, arriving in Buffalo Niagara.Price includes taxes and charges.From £482, select.

Find the cheapest month to fly from Buffalo Niagara to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Buffalo Niagara to Knoxville flights are currently cheapest in May.
Feb
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Mar
from £243
Apr
from £235
May
from £195
Jun
from £250
Jul
from £332
Aug
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Sep
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Oct
from £291
Nov
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Dec
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Jan
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Buffalo Niagara to Knoxville: Alternative routes

Compare routes from Buffalo Niagara to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Knoxville

11 miles from central Knoxville
ClosestCheapest
from £195
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Buffalo to Knoxville: Flight information

The things to know before you go.
Cheapest flight found£195
Cheapest month to flyMay

Finding cheap flights from Buffalo Niagara to Knoxville: Frequently asked questions

The best price we found for a return flight from Buffalo Niagara to Knoxville is £195. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Buffalo Niagara to Knoxville. But we found flights with one or more stops from £195.
As of February 2026, there are no flights flying from Buffalo Niagara to Knoxville.
The cheapest month to fly from Buffalo Niagara to Knoxville is usually May.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Buffalo Niagara Airport to Knoxville Airport on Saturday, 2 May 2026.
No airlines currently offer direct flights between Buffalo Niagara Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Frontier Airlines offers the cheapest flight tickets to Knoxville.

Flying from Buffalo Niagara International Airport (BUF) to McGhee Tyson Airport (TYS): what you need to know

  • Arriving two hours before an international flight and one hour ahead of a domestic departure are travel rules worth sticking to. Make sure you're at the airport on time to board your BUF to TYS flight.

  • Flying during a peak time like August? School holidays and other popular seasons can lead to longer lines and delays at airport checkpoints. Be extra cautious and arrive up to four hours before an international flight and two hours before a domestic departure.

  • If you want to include a stop along the way, just uncheck 'Direct flights only' when searching for your ticket from Buffalo Niagara International Airport to McGhee Tyson Airport. These are the most popular stopovers between BUF and TYS:

    • Detroit Metropolitan Wayne County Airport

    • Charlotte Douglas International Airport

    • Hartsfield-Jackson Atlanta International Airport

How to find the cheapest flights from Buffalo Niagara International Airport (BUF) to McGhee Tyson Airport (TYS)

  • The cheapest price we've found for a one-way Buffalo Niagara International Airport to McGhee Tyson Airport flight is £124. A return plane ticket right now is £195. Depending on the availability and when you book, these fares can change.

  • It's usually smart to book as early as possible if you're looking for cheap tickets from BUF to TYS. That's because airlines change prices based on demand, which tends to increase closer to departure.

  • If you can be flexible with your trip dates, try using the 'Whole month' search function. It'll find the lowest price across every month when searching for your flight from Buffalo Niagara International Airport to McGhee Tyson Airport.

  • There's no need to check every day to find out if fares have gone down when you create a Price Alert. We'll let you know the moment the price changes on cheap flights from BUF to TYS.

  • Select your preferred arrival and departure times, airlines and number of stops with the filters. Alternatively, sort your results by 'Cheapest' to see the best deals on flights from Buffalo Niagara International Airport to McGhee Tyson Airport.

Handy information about Buffalo Niagara International Airport (BUF)

  • BUF's address is Genesee Street.

  • When it comes to the on-time performance of Buffalo Niagara International Airport, data shows 75.46% of flights meet their scheduled arrival time.

  • Central Buffalo to Buffalo Niagara International Airport is approximately 11 miles. Depending on traffic, it'll take you about 20 minutes to get there if you're driving, catching a cab or ride-sharing.

  • Taking public transport? You can expect a journey time of around 1 hour 15 minutes.

  • Have an early flight from Buffalo Niagara International Airport to McGhee Tyson Airport? Avoid rushing to the airport (and get some extra shut-eye) by picking one of these stays near BUF:

Arriving at McGhee Tyson Airport (TYS)

  • Consider staying in a hotel close to TYS if you're taking a late Buffalo Niagara International Airport to McGhee Tyson Airport flight. Check in to one of these accommodation options and avoid the hassle of a long transfer:

  • Go wherever you want, whenever you want with a McGhee Tyson Airport rental car. Pick up your wheels from Budget, Alamo or Avis and discover more of Knoxville and beyond.

  • Booking your vehicle from McGhee Tyson Airport around three weeks ahead can help you secure the lowest rate.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

  • The street address for TYS is 2055 Alcoa Highway.

  • McGhee Tyson Airport to central Knoxville has a drive time of about 20 minutes. It's approximately 14 miles away.

When to fly to McGhee Tyson Airport (TYS)

  • It's time to work out your travel dates for your flight from Buffalo Niagara International Airport to McGhee Tyson Airport. July is the busiest month to visit Knoxville. If you're after a more low-key vibe, go in February.

  • The warmest month in Knoxville is July, with the temperature ranging between 17ºC (63ºF) and 32ºC (90ºF). Book your flights from Buffalo Niagara International Airport to McGhee Tyson Airport in this month if this is the kind of weather you like.

  • January has average temperatures of between -6ºC (21ºF) and 11ºC (52ºF). Look for cheap tickets from BUF to TYS sometime around then if you like travelling in cooler conditions.

Explore more of United States

  • You've visited Knoxville, now it's time to discover other parts of United States. Travel about 280 miles north to Columbus to check off its popular sights. From Franklin Park Conservatory and Botanical Gardens to Ohio Statehouse and German Village, there's plenty to keep you on the go.

  • Around 290 miles north-west of Knoxville, Indianapolis is another favourite stop in United States. Experience this destination's highlights firsthand at The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo.

Plan the rest of your trip from Buffalo to Knoxville

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.