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Cheap Flights from Des Moines (DSM) to Key West International (EYW)

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Flight deals from Des Moines to Key West International

Looking for a cheap last-minute deal or the best return flight from Des Moines to Key West International? Find the lowest prices on one-way and return tickets right here.
Key West.£212 per passenger.Departing Sat, 7 Mar, returning Wed, 11 Mar.Return flight with Frontier Airlines and Breeze Airways.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Sat, 7 Mar, arriving in Key West International.Inbound indirect flight with Breeze Airways, departs from Key West International on Wed, 11 Mar, arriving in Des Moines.Price includes taxes and charges.From £212, select.
Key West.£214 per passenger.Departing Fri, 28 Aug, returning Mon, 31 Aug.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Fri, 28 Aug, arriving in Key West International.Inbound indirect flight with United, departs from Key West International on Mon, 31 Aug, arriving in Des Moines.Price includes taxes and charges.From £214, select.
Key West.£260 per passenger.Departing Sun, 12 Apr, returning Fri, 17 Apr.Return flight with Allegiant Air and Breeze Airways.Outbound indirect flight with Allegiant Air, departs from Des Moines on Sun, 12 Apr, arriving in Key West International.Inbound indirect flight with Breeze Airways, departs from Key West International on Fri, 17 Apr, arriving in Des Moines.Price includes taxes and charges.From £260, select.
Key West.£273 per passenger.Departing Fri, 27 Feb, returning Thu, 5 Mar.Return flight with Allegiant Air.Outbound indirect flight with Allegiant Air, departs from Des Moines on Fri, 27 Feb, arriving in Key West International.Inbound indirect flight with Allegiant Air, departs from Key West International on Thu, 5 Mar, arriving in Des Moines.Price includes taxes and charges.From £273, select.
Key West.£277 per passenger.Departing Sat, 2 May, returning Sat, 9 May.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Sat, 2 May, arriving in Key West International.Inbound indirect flight with Delta, departs from Key West International on Sat, 9 May, arriving in Des Moines.Price includes taxes and charges.From £277, select.
Key West.£283 per passenger.Departing Sat, 28 Mar, returning Sat, 4 Apr.Return flight with Allegiant Air.Outbound indirect flight with Allegiant Air, departs from Des Moines on Sat, 28 Mar, arriving in Key West International.Inbound indirect flight with Allegiant Air, departs from Key West International on Sat, 4 Apr, arriving in Des Moines.Price includes taxes and charges.From £283, select.
Key West.£395 per passenger.Departing Wed, 4 Nov, returning Sat, 7 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Wed, 4 Nov, arriving in Key West International.Inbound indirect flight with Delta, departs from Key West International on Sat, 7 Nov, arriving in Des Moines.Price includes taxes and charges.From £395, select.
Key West.£598 per passenger.Departing Fri, 23 Oct, returning Mon, 26 Oct.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Fri, 23 Oct, arriving in Key West International.Inbound indirect flight with Delta, departs from Key West International on Mon, 26 Oct, arriving in Des Moines.Price includes taxes and charges.From £598, select.

Find the cheapest month to fly from Des Moines to Key West International

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Key West International flights are currently cheapest in March.
Feb
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Mar
from £212
Apr
from £260
May
from £277
Jun
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Jul
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Aug
from £214
Sep
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Oct
from £598
Nov
from £395
Dec
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Jan
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Des Moines to Key West International: Alternative routes

Compare routes from Des Moines to Key West below. You may find an airport to fly into that's cheaper, faster, or easier than Key West International.

Key West International

3 miles from central Key West
ClosestCheapest
from £212
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Des Moines to Key West: Flight information

The things to know before you go.
Cheapest flight found£212
Cheapest month to flyMarch

Finding cheap flights from Des Moines to Key West International: Frequently asked questions

The best price we found for a return flight from Des Moines to Key West International is £212. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to Key West International. But we found flights with one or more stops from £212.
As of February 2026, there are no flights flying from Des Moines to Key West International.
The cheapest month to fly from Des Moines to Key West International is usually March.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Key West International Airport on Saturday, 7 March 2026.
No airlines currently offer direct flights between Des Moines Airport and Key West International Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Key West International but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Key West is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Frontier Airlines offers the cheapest flight tickets to Key West International.

Flying from Des Moines International Airport (DSM) to Key West International Airport (EYW): what you need to know

  • Give yourself enough time to catch your DSM to EYW flight. It's generally best to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • During popular months such as July, it's best to get to the airport even earlier. Plan to arrive two hours before a domestic departure and four hours ahead for an international flight whenever you're travelling during peak periods in general.

  • If you'd like to include a stop along the way, just deselect 'Direct flights only' when searching for your ticket from Des Moines International Airport to Key West International Airport. These are the top stopovers between DSM and EYW:

    • Fort Lauderdale-Hollywood International Airport

    • O'Hare International Airport

    • Charlotte Douglas International Airport

How to find the cheapest flights from Des Moines International Airport (DSM) to Key West International Airport (EYW)

  • The lowest price we've found for a one-way Des Moines International Airport to Key West International Airport flight is £225. A round-trip fare is currently £212. Depending on the availability and when you book, these fares can change.

  • To get your hands on cheap tickets from DSM to EYW, book in advance. Airlines usually offer lower fares when flights are first released.

  • Finding cheap flights from Des Moines International Airport to Key West International Airport is easy if you can be flexible with your travel plans. Use the 'Whole month' search function to see the lowest fares across the month and bag a great deal.

  • Snapping up cheap flights from DSM to EYW is easy with Price Alerts. All you need to do is set up one of these automatic alerts and we'll let you know when a lower fare pops up.

  • Tailor your trip with filters. Choose your arrival and departure times, airlines and total journey duration. You can also sort results by 'Fastest,' 'Best' or 'Cheapest' flights from Des Moines International Airport to Key West International Airport.

Handy information about Des Moines International Airport (DSM)

  • DSM's address is 5800 Fleur Drive, Suite 201.

  • 80.45% of flights leaving Des Moines International Airport touch down at their destination on schedule. Given its strong on-time performance, you're unlikely to experience delays when taking off from DSM.

  • To reach Des Moines International Airport from central Des Moines, it takes around 15 minutes if you're travelling by car. Of course, this depends on traffic. It's approximately 6 miles from the airport to the city centre.

  • The trip on public transport takes about 45 minutes.

  • Get your travels off to a relaxed start by staying near DSM. Whether you're taking an early flight from Des Moines International Airport to Key West International Airport or just don't want to be rushed, these hotels are perfect:

Arriving at Key West International Airport (EYW)

Getting from Key West International Airport (EYW) to central Key West

  • EYW is located at 3491 South Roosevelt Boulevard.

  • Key West International Airport is approximately 2 miles from central Key West. Driving there takes about 5 minutes.

  • It takes roughly 40 minutes if you're using public transport.

When to fly to Key West International Airport (EYW)

  • It's time to choose your trip dates for your flight from Des Moines International Airport to Key West International Airport. January is the busiest month to head to Key West. If you like a more laid-back vibe, go in February.

  • Before locking in your flight from Des Moines International Airport to Key West International Airport, think about the kind of weather you like. August is the warmest month in Key West, with temperatures ranging from 26ºC (79ºF) to 30ºC (86ºF).

  • Search for cheap tickets from DSM to EYW in January if you'd rather travel during cooler conditions. Temperatures are at their lowest around then, ranging between 18ºC (64ºF) and 23ºC (73ºF) on average.

Explore more of United States

  • Key West has its own special appeal, but there are so many other parts of United States waiting to be discovered. Around 130 miles north-east of Key West, a visit to Miami will keep you on the move. Start with attractions like Wynwood Walls, Vizcaya Museum and Gardens and American Airlines Arena.

  • If you want to check out another major stop in United States, consider Tampa, about 240 miles north of Key West. Ybor City Tattoo Company, Tampa Riverwalk and The Florida Aquarium are highlights.

Plan the rest of your trip from Des Moines to Key West

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.