Skyscanner home

Cheap Flights from Denver International (DEN) to Panama City (PTYA)

Compare Denver International to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

Book the best Panama City fare with no extra fees

Flight deals from Denver International Airport to Panama City

Looking for a cheap last-minute deal or the best return flight from Denver International Airport to Panama City? If you want to travel next month, return fares start from £346. Find the lowest prices on one-way and return tickets right here.
Panama City.£294 per passenger.Departing Fri, 20 Feb, returning Mon, 9 Mar.Return flight with Frontier Airlines and Avianca.Outbound indirect flight with Frontier Airlines, departs from Denver International on Fri, 20 Feb, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 9 Mar, arriving in Denver International.Price includes taxes and charges.From £294, select.
Panama City.£309 per passenger.Departing Wed, 1 Apr, returning Sat, 11 Apr.Return flight with Frontier Airlines and Avianca.Outbound indirect flight with Frontier Airlines, departs from Denver International on Wed, 1 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 11 Apr, arriving in Denver International.Price includes taxes and charges.From £309, select.
Panama City.£331 per passenger.Departing Mon, 11 May, returning Fri, 22 May.Return flight with Frontier Airlines and Avianca.Outbound indirect flight with Frontier Airlines, departs from Denver International on Mon, 11 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 22 May, arriving in Denver International.Price includes taxes and charges.From £331, select.
Panama City.£336 per passenger.Departing Mon, 9 Mar, returning Mon, 16 Mar.Return flight with Frontier Airlines and Avianca.Outbound indirect flight with Frontier Airlines, departs from Denver International on Mon, 9 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 16 Mar, arriving in Denver International.Price includes taxes and charges.From £336, select.
Panama City.£345 per passenger.Departing Sat, 28 Mar, returning Sat, 4 Apr.Return flight with Frontier Airlines and Avianca.Outbound indirect flight with Frontier Airlines, departs from Denver International on Sat, 28 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 4 Apr, arriving in Denver International.Price includes taxes and charges.From £345, select.
Panama City.£346 per passenger.Departing Thu, 19 Feb, returning Tue, 24 Feb.Return flight with Frontier Airlines and Avianca.Outbound indirect flight with Frontier Airlines, departs from Denver International on Thu, 19 Feb, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Tue, 24 Feb, arriving in Denver International.Price includes taxes and charges.From £346, select.
Panama City.£411 per passenger.Departing Tue, 27 Jan, returning Tue, 24 Feb.Return flight with Volaris and Avianca.Outbound indirect flight with Volaris, departs from Denver International on Tue, 27 Jan, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Tue, 24 Feb, arriving in Denver International.Price includes taxes and charges.From £411, select.
Panama City.£413 per passenger.Departing Thu, 30 Apr, returning Sun, 3 May.Return flight with Frontier Airlines and Avianca.Outbound indirect flight with Frontier Airlines, departs from Denver International on Thu, 30 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 3 May, arriving in Denver International.Price includes taxes and charges.From £413, select.
Panama City.£422 per passenger.Departing Sat, 16 May, returning Sat, 23 May.Return flight with Copa.Outbound direct flight with Copa departs from Denver International on Sat, 16 May, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sat, 23 May, arriving in Denver International.Price includes taxes and charges.From £422, select.
Panama City.£422 per passenger.Departing Wed, 29 Apr, returning Thu, 28 May.Return flight with Copa.Outbound direct flight with Copa departs from Denver International on Wed, 29 Apr, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Thu, 28 May, arriving in Denver International.Price includes taxes and charges.From £422, select.

Find the cheapest month to fly from Denver International to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Denver International to Panama City flights are currently cheapest in April.
Jan
Find prices
Feb
from £346
Mar
from £336
Apr
from £309
May
from £331
Jun
from £463
Jul
from £547
Aug
from £426
Sep
from £422
Oct
from £433
Nov
Find prices
Dec
Find prices

Direct flights from Denver International to Panama City

Alternative Denver International to Panama City routes

Looking for the cheapest, fastest or easiest route from Denver International to Panama City? You could fly into the following airports instead.

Panama City Paitilla

3 miles from central Panama City
Closest
Search flights

Balboa

3 miles from central Panama City
from £443
Search flights

Panama City Tocumen International

11 miles from central Panama City
Cheapest
from £294
Search flights

Denver to Panama City: Flight information

The things to know before you go.
Cheapest flight found£294
Cheapest month to flyFebruary
Average flight time5 hrs, 48 mins
Most popular airlineCopa
Average flights per week31

Finding cheap flights from Denver International to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Denver International to Panama City is £294. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
5 hours and 48 minutes is the average flight time from Denver International to Panama City.
Copa and United fly direct from Denver International to Panama City.
As of January 2026, there are 31 flights per week flying from Denver International to Panama City.
The cheapest month to fly from Denver International to Panama City is usually February.
If you're flying from Denver International Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 11.1 miles away from the centre of Panama City. We've found flights into this airport from £294.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Denver International Airport to Panama City on Friday, 20 February 2026.
Yes – the average flight time is 5 hours and 48 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In January, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, Frontier Airlines and Copa offer the cheapest flight tickets to Panama City.

Travelling from Denver International Airport (DEN) to Panama City: what you need to know

  • Expect to be in the air for 6 hours 15 minutes. That's the average journey time for a direct flight from Denver International Airport to Panama City.

  • Denver International Airport is located in Denver. Based in the UTC-5 timezone, Panama City is one hour ahead of Denver.

  • With six flights a week between the two airports, Denver International Airport (DEN) to Tocumen International Airport (PTY) is the busiest route. Hop on Copa Airlines's 20:19 flight to get your journey from DEN to PTY underway.

  • Give yourself plenty of time to make your DEN to Panama City flight. Generally, it's best to arrive two hours before international departures and an hour ahead for domestic flights.

  • Delays at check-in and security are more likely if you're flying during high season, so allow a bit more breathing room. A good general rule for peak times? Arrive up to four hours early for international flights and two hours for domestic departures.

  • Direct Denver International Airport to Panama City tickets are available for booking. Tocumen International Airport (PTY) is where you'll step off the plane.

  • Keep an eye out for promotions from Copa Airlines. This carrier operates direct flights from Denver International Airport to Panama City.

  • Stopovers are the perfect opportunity to break up your trip and possibly even explore another city. When browsing for plane tickets from DEN to Panama City, deselect the 'Direct flights only' box to see where you can visit along the way. Consider one of these popular options:

    • George Bush Intercontinental Airport (IAH)

    • Orlando International Airport (MCO)

    • Cancun International Airport (CUN)

  • DEN is about 19 miles from central Denver. If you're ride-sharing, catching a cab or driving from the centre, it'll take 35 minutes or so to get there, depending on traffic conditions. If you're taking public transport, expect the travel time to be around 1 hour 30 minutes.

  • Get your flight from Denver International Airport to Panama City off to a hassle-free start. Just a quick drive from DEN, spend the night at The Westin Denver International Airport and you'll be well-rested for the trip ahead.

  • Denver International Airport gets high marks for on-time performance. 80.23% of flights that take off from DEN reach their destination on time.

  • DEN is located at 8500 Pena Boulevard.

How to find the cheapest flights from Denver International Airport (DEN) to Panama City

  • £122 is currently the lowest price for a one-way Denver International Airport to Panama City flight. A return plane ticket starts at £294. These prices may change depending on availability.

  • Get cheap flights from DEN to Panama City by booking one month ahead. Based on our research, that's the sweet spot for picking up a bargain.

  • Organise your trip for May. That's the best month for scoring a bargain on Denver International Airport to Panama City tickets. If you're flexible on when you fly, use the 'Whole month' tool to find the lowest price across every month.

  • Cut down on the time spent looking for cheap flights from DEN to Panama City by setting up a Price Alert. We'll send you an email or notification on the app when a special offer becomes available.

  • Pick your preferred arrival and departure times, number of stops and airlines with our filters. Then, sort the results for your flight from Denver International Airport to Panama City by 'Best,' 'Cheapest' or 'Fastest.'

Airports in Panama City

Tocumen International Airport (PTY)

  • Tocumen International Airport (PTY) is around 13 miles from the centre of Panama City. If you're getting a cab or a ride-share, the drive takes roughly 20 minutes.

  • If you're travelling by public transport, expect a journey time of about 1 hour 5 minutes.

  • If you're arriving on a late flight from Denver International Airport to Panama City, few things beat the convenience of staying near the terminal. Grab your luggage from the carousel and then be showered and resting not long after at one of these hotels near PTY:

  • Fast-track your adventure by picking up a Tocumen International Airport rental car. Grab a set of wheels from Avis, Dollar or MEX and experience the lesser-explored corners of Panama City and beyond.

  • Booking your vehicle from Tocumen International Airport about three weeks in advance of your flight from DEN to Panama City can help you lock in the best possible rate.

Marcos A. Gelabert International Airport (PAC)

  • After your flight from Denver International Airport to Panama City has arrived, you can reach the city centre in about 5 minutes by car. Central Panama City is roughly 1 mile from Marcos A. Gelabert International Airport (PAC).

  • If you choose to travel on public transport, you'll get to the city centre in 25 minutes or so.

  • There are some comfortable places to park your luggage (and yourself) near PAC. Settle in and get cosy after your DEN to Panama City flight at any of these well-located options:

  • The fastest way to reach your destination is with a Marcos A. Gelabert International Airport rental car. Pick up a set of wheels from Thrifty, Avis or Alamo and hit the road in a heartbeat.

  • Get first dibs on the best options. Reserving your ride from PAC three weeks ahead of time often means lower prices and a wider range of vehicles.

Panama Pacifico Airport (BLB)

  • Panama Pacifico Airport (BLB) is around 10 miles from central Panama City. It takes about 20 minutes to get to the city centre in a ride-share or cab after your flight from Denver International Airport to Panama City.

  • Enjoy a low-stress, comfortable start to your break by choosing a hotel near BLB after your DEN to Panama City flight. Rest up after a long day of travel or just take a moment to find your footing in a new place at:

  • Whether you're searching for a mini for a solo trip or an SUV to fit everyone and their gear, you'll find the perfect Panama Pacifico Airport rental car for your needs. Check out the types of wheels available from names such as Sixt, Dollar and Thrifty.

  • Around one week before your flight from Denver International Airport to Panama City is a good time to book your vehicle from BLB. You're more likely to find a cheaper rate or even pick up some early bird discounts.

Best time to go to Panama City

  • Carefully consider your dates before locking in your flight from Denver International Airport to Panama City. The city comes alive in peak season, but prices are typically higher and major attractions can get busy. Go to Panama City in low season if you like a more relaxed vibe.

  • The warmest month in Panama City is March, with temperatures ranging between 21ºC (70ºF) and 32ºC (90ºF). Book your Denver International Airport to Panama City plane ticket then if that's your ideal forecast.

  • Search for cheap tickets from DEN to Panama City in February if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

  • When it comes to looking for somewhere to rest your head, you'll find the best places to stay in Panama City right here. Check out these options once you've booked your flight from Denver International Airport to Panama City:

  • Casco Viejo and Panama Canal Museum are just a couple of the top-rated attractions to put on your Panama City must-do list. Continue your sightseeing adventures at Cinta Costera.

Explore more of Panama

  • Panama City has loads to offer, but there are so many other parts of Panama you'll want to see. About 200 miles west of Panama City, a visit to David will fill your itinerary to the brim. Check out popular attractions like Parque Cervantes, Altos del Rio Park and Coquito Hills Park.

  • Around 120 miles south-west of Panama City, Santiago de Veraguas is another essential stop in Panama. No visit is complete without checking out Santiago the Apostle Cathedral, Santiago de Veraguas, The Church of Jesus Christ of Latter Day Saints and La Placita San Juan De Dios.

Plan the rest of your trip from Denver to Panama City

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.