Flights from the southern German town will travel to Alghero (Sardinia), Alicante, Barcelona (Girona), Barcelona (Reus), Dublin, Stansted and Pisa.
Just over half a million passengers will be transported on the new routes every year, which will also help to sustain 500 new jobs in the region.
Ryanair chief executive officer Michael O’Leary said that the airline is "delighted" to link up with Memmingen Airport.
"Memmingen, which is approximately 100km west of Munich, provides Ryanair with a first and ideal gateway to southern Germany and the Bavarian region," he said.
To celebrate the launch of the new route, Ryanair is reducing the price of one million of its lowest fares by 50 per cent on flights in its European network during April, May and June.
The airline announced earlier this month that it planned to introduce a 100 percent online check-in service from October 1st.