Flights to the Angolan capital will operate three times a week, on Tuesdays, Thursdays and Sundays.
Emirates’ president Tim Clark said the new route "provides enormous potential to develop air travel in Angola".
"In the past year, we have seen strong growth in Africa of 17 percent," he commented.
"Now, with Luanda starting in August and Durban starting later in the year, this is going to be another very exciting year in this largely untapped continent."
Emirates will begin flying to the South African city of Durban on October 1st.
An Airbus A330-200 will be operated on the route, which will support Angola’s fledgling tourism market as well as help the country’s migrant workers, many of whom hail from China.
Emirates will increase its number of flights to Dammam, Beirut and Tehran from May 1st.