Cheap flights carrier Ryanair will switch nine of its Manchester routes to East Midlands, Leeds Bradford and Liverpool airports.
Flights to Barcelona (Girona), Bremen, Brussels (Charleroi) and Cagliari are among those affected, while routes to Dusseldorf (Weeze), Frankfurt (Hahn), Marseille, Milan (Bergamo) and Shannon will also be changed from October 1st.
Elsewhere, the airline said that it expects to expand its operations from cheap flights airports Leeds Bradford and Porto.
Stephen McNamara, of Ryanair, explained that the routes were being switched because Manchester had become too expensive.
"Ryanair will continue to grow at low cost airports which work with us to deliver the low fares required to keep passengers flying during this recession," he commented.
Mr McNamara added that the airline would contact passengers affected by the changes in the coming weeks, offering them either a full refund or an alternative flight from East Midlands, Leeds Bradford or Liverpool.
Ryanair recently announced its intention to launch 43 new flights to Spain from a number of UK airports.