The daily flights will operate between the north-east airport and Plymouth Airport using one of the low-cost regional airline’s fleet of Bombardier jets.
Mike Coombes, deputy chief executive of Air Southwest, commented: "We are delighted to be starting daily flights to and from the south-west at Newcastle. I am confident that the new services will benefit the local economy by increasing the number of business and leisure visitors to the city and wider north-east region."
Mr Coombes also explained that as well as appealing to business travellers, the new route will benefit holidaymakers, making it easier to reach the south-west coast from the north-east for short breaks.
The year-round flights are the latest additions to Newcastle Airport’s growing schedule with recent expansions to both domestic and international services announced.
Regional carrier Eastern Airways bolstered its offerings from Newcastle with more flights to Cardiff and a new route to the Norwegian city of Stavanger earlier this month, while Jet2 offered Tynesiders access to the Greek islands with flights to Corfu and Rhodes.