It is the first time that flights from Leeds to the Big Apple have been available to airline passengers.
Jet2.com’s New York flights start at £579.98 including taxes. In addition, Jet2holidays.com will offer four-day Christmas shopping breaks, reports Peanuts.aero.
Richard Bodin, managing director at Jet2holidays.com, said: "This is an important announcement for us. We knew this destination was one that our customers have been calling for and we are proud and thrilled to be able to be the first holiday company in the region to offer this great deal."
Jet2 said that if demand is high enough it will increase the number of New York-bound planes leaving Leeds Bradford.
Earlier this month, Jet2 launched the first of eight new routes to Europe from Leeds as part of its expansion at the airport.