The weekly flight – the only service to Israel’s second city from the north – will commence from May 21st, with the frequency expected to increase to twice per week in October.
Commenting on the new flight, Jet2 chief Philip Meeson said that Tel Aviv is an "extremely popular destination" and that he was confident that demand would be high for the flight.
"As the only direct route from the north, we are in an unrivalled position to offer both the lowest ever fares and fastest service into Israel," he said.
"This route launch is extremely significant for Jet2.com and emphasises our drive to continue to innovate and expand our reach into a variety of countries and markets."
As well as offering a link to the north’s Jewish community, the flight will also be attractive to those seeking a weekend break in Tel Aviv, with the city offering exciting nightlife, a charming beach and an historic old quarter.
Jet2 commenced flights from Leeds Bradford Airport in 2003 and announced the launch of its second base at Manchester in September 2004.