United Airlines will launch new flights to Duluth and Asheville from Chicago later this winter.
The carrier will also introduce flights to Midland/Odessa, while a once-daily flight will link the Colorado city with Louisville in Kentucky.
Elsewhere, United will begin flights to El Paso from Los Angeles, with the new routes due to take effect on December 17th.
The services will be operated using CRJ-200 regional jets, which have a capacity of 50 people. SkyWest Airlines will manage the routes on behalf of United Airlines.
Minnesota congressman Jim Oberstar, chairman of the house transportation and infrastructure committee, explained that air services are "vital to our regional economy".
"United’s investment in Duluth is adding momentum to that effort, and these additional flights will give travellers more ways to come to the Twin Ports for business and tourism," he said.
On September 29th, United will launch new non-stop flights to London, Ontario from Chicago.
The airline operates approximately 3,300 flights a day to 200 domestic and international locations.