The new service will take the number of South African markets served by Emirates up to three, with the airline offering daily flights to Johannesburg since 2007.
Tim Clark, president of Emirates Airline, said: "I am confident the new service will foster greater business, tourism and cultural exchange, and prove an asset in the growth plans of Durban.
"Our flights will provide travellers from key cities in Europe, the Indian-sub continent and Middle East a direct access to Durban and will strengthen inbound tourist arrivals."
He added that passengers flying from Durban will have direct access to over 90 destinations and will be able to reach the Middle East without travelling to Johannesburg.
As well as expanding its presence in South Africa, Emirates will boost its profile in China with new flights to Guangzhou in July. The daily service will join existing flights to Beijing, Shanghai and Hong Kong.