The twice-daily service began yesterday (April 20th), with people in the capital now having the chance to arrive in the far south-west in little more than one hour.
Peter Davies, Air Southwest’s managing director, said that the carrier is "revolutionising" air travel between London and the south-west and giving passengers "a real choice".
"These flights fit the busy working lives of our business customers and are ideal for London City passengers looking to visit friends and family or make the most of a short break in Cornwall and Devon without the high costs of the eurozone," he commented.
The airline revealed that 5,000 seats have been sold for the flights, with tickets costing from £29.
Operating twice-daily on weekdays, the route will also run once a day on Sundays.
VLM airlines will launch new flights to Nantes from the Docklands airport on April 27th.