Luggage will only need to be checked once and connecting flights with the three carriers will open up the number of routes available from Flybe's UK bases.
Stephen Hobday, head of sales at Flybe, said: "Our continued pursuit and implementation of interline e-ticket projects endorses Flybe's commitment to increasing our interline partnerships.
It also enables our travel trade partners to issue more tickets to an even greater number of destination options and demonstrates our determination to expanding and strengthening our connecting route network."
VRG's latest ticketing partnership was announced just last week and brings Panama-based Copa Airlines to the fold. This will allow passengers to fly on VRG domestic flights and onwards to international destinations with Copa.
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