The regional airline has said that it wants to increase capacity on the route, particularly after bmibaby's announcement comes into effect on March 29th.
Mike Rutter, Flybe's chief commercial officer, said that the news that bmibaby had cancelled its flight between Cardiff and Glasgow "should not really come as a surprise".
"We look forward to welcoming our new customers on this important route and again reaffirm our determination to serving the people of Wales and to becoming Cardiff's number one airline" he said.
Flybe has announced a special promotion on its existing flight between the two cities by reducing ticket prices by up to 50 percent.
Flybe, Europe's largest regional carrier recently won the 2009 Regional Airline of the Year award from US publication Air Transport World.