The destination the 17th to be added from the north-east terminal and will operate three times a week.
Carly Brear UK commercial manager for easyJet, said: "Murcia is already a popular destination from other easyJet bases in the UK and now travellers from the north-east can take advantage of one of the most popular destinations on the east coast of Spain.
Forward bookings for the route have been very strong, which further proves the demand for direct low-fare flights from Newcastle to the sun."
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