Routes to the French Alps destination will operate from all four of the airline's UK airports - East Midlands, Manchester, Birmingham International and Cardiff.
Commenting on the schedule, which comes into effect on October 25th, bmibaby managing director Crawford Rix said: "Grenoble is located in the very centre of the Alps and will be an extremely popular destination for those looking for a winter snow holiday.
"We expect to carry over 28,700 passengers to and from Grenoble over the winter months."
In addition, bmibaby will continue operating flights to Toulouse from Manchester during the winter months.
A new route will also be introduced to Prague from Belfast, with flights scheduled to depart on Monday, Friday and Sunday.
Flights to the Czech capital will be introduced on December 4th.
Bmibaby recently revealed that 84.4 percent of its February flights departed within 15 minutes of schedule, while the figure for January stood at 90.8 percent.