The carrier will operate three daily flights between the destinations from June 1st, with the move promoted by increased passenger demand.
CityFlyer managing director, Peter Simpson, said: "Dublin is an important new route, linking two financial capitals, and we are delighted to be able to offer a three-a-day service in direct response to passenger demand."
This announcement comes alongside plans from CityFlyer to bolster its existing schedule with a second daily flight from London City to Nice which will launch in September.
Other new routes planned from the Docklands airport include four daily flights to Amsterdam, six flights a week to Barcelona and three weekday services to Warsaw – all of which are due to start on May 6th.
Connecting the capital with other key cities appears to be a priority for CityFlyer, which will also increase frequency on London to Edinburgh services in September.
The moves have been welcomed by London City Airport – with Dublin now the tenth destination served by BA from the Docklands terminal.
"This announcement comes at a significant time as the airport is close to completing the current phase of development including an extension to the departure lounge and new aircraft parking stands," commented the airport's chief executive Richard Gooding.
"British Airways' commitment to our Docklands hub is recognised by the business community who will appreciate the additional frequencies available to them."